Resident Evil 6 uses an older engine variant that struggle to read file paths containing special characters, non-English accents, or symbols.

How to Fix the "Resident Evil 6 Fatal Error: Failed to Open File" on Windows

The exact filename in the error tells you which asset is failing – search that filename online for mod-specific or hardware-specific fixes.

In the folder that opens, locate (the main game executable). Right-click BH6.exe and select Properties . Go to the Compatibility tab. Check the box next to Run this program as an administrator . Click Apply and then OK . 3. Check for conflicting mods or leftover files