DMC4 is an older DX11 title. Modern GPUs (RTX 30/40 series, RX 6000/7000 series) boost so aggressively that they cause instability in legacy engines.
Locate the line FullScreen=ON and change it to FullScreen=OFF .
: Conflicting resolutions or refresh rates between your monitor and the game's config.ini file trigger startup crashes. Step-by-Step Solutions to Fix the Error 1. Implement the Legacy DLL File Drop
: Overclocking or undervolting settings that work in other games may trigger this error in DMC4SE.
Background applications and certain NVIDIA features have been known to interfere with the game's rendering process.