Launch Steam at home, set it to Offline Mode, and bring your personal laptop to school or work. You can play your installed games without needing an internet connection.
Third-party unblocked game sites typically aren't vetted for safety. Many are hosted on free platforms like Weebly and other site builders, and they can include intrusive ads, pop-ups, or even malicious code. Some unofficial Chrome extensions claiming to offer the game may also request permissions they don't need. The Binding Of Isaac Unblocked Full Game No
The Binding of Isaac has been blocked on many networks due to its mature content, including: Launch Steam at home, set it to Offline
Getting red hearts is important, but Soul Hearts and Black Hearts are better because they don't affect your chances of finding "Devil Deals" on later floors. Launch Steam at home